Daunotec 20 Mg Injection

Product Description

1. Technical Specifications

2. Product Description

Daunotec 20 mg Injection contains Daunorubicin, an anthracycline class chemotherapy drug. It works by intercalating into DNA, inhibiting topoisomerase II, and generating free radicals, causing DNA strand breaks and apoptosis in rapidly dividing cancer cells. It is widely used in acute leukemias as part of induction chemotherapy regimens.

3. Product Highlights

4. Therapeutic Uses

• Acute Myeloid Leukemia (AML): Used in induction therapy (e.g., 7+3 regimen with cytarabine).

• Acute Lymphoblastic Leukemia (ALL): Incorporated in multi-agent treatment regimens.

• May be included in other leukemia treatment protocols as directed by oncologists.

5. Side Effects

Common:

• Bone marrow suppression (neutropenia, anemia, thrombocytopenia)

• Nausea, vomiting

• Stomatitis, mucositis

• Alopecia

• Harmless red-orange urine discoloration

Serious / Severe:

• Cardiotoxicity (arrhythmias, cardiomyopathy, heart failure) dose dependent

• Severe infections due to myelosuppression

• Extravasation injury tissue necrosis

• Hepatic and renal toxicity (with impaired function)

• Secondary malignancies (rare, long-term risk)

6. Precautions

• Cardiac Safety: Baseline and periodic echocardiogram/LVEF monitoring; cumulative dose limits must be respected.

• Hematologic Monitoring: Frequent CBCs; manage neutropenia with growth factors if required.

• Liver & Kidney Function: Dose adjustments may be necessary; monitor LFTs and creatinine.

• Extravasation Risk: Administer through central line; stop infusion immediately if leakage occurs.

• Drug Interactions: Additive cardiotoxicity with trastuzumab, cyclophosphamide, or prior chest irradiation; avoid strong CYP/P-gp modulators.

• Pregnancy & Lactation: Contraindicated; requires effective contraception during and after treatment.

• Supportive Care: Antiemetics, oral hygiene, and infection prophylaxis should be part of supportive regimen.

Effective Cancer Therapy

Daunotec 20 mg Injection provides a reliable solution for certain cancers, offering a potent treatment option administered by professionals. As a carefully formulated injectable drug, it ensures a controlled and accurate dosage under strict medical supervision.


Handling and Storage

This medication should be kept in a cool and dry place to maintain its efficacy and shelf life. Proper storage prevents degradation and ensures that the drug remains safe for adult patients when administered according to instructions.


Medical Expertise and Distribution

Daunotec 20 mg Injection is recommended strictly for use by doctors and is available through authorized distributors, exporters, and suppliers in India. Its accessibility through trusted channels supports precise and safe usage in healthcare facilities.