Voriconazole Tablet IP

Product Description

1. Technical Specifications

Manufactured By: Zydus Lifesciences Ltd.

Packaging Size: 1 x 4 Tablets (strip)

Packaging Type: Blister strip in box

Dosage Form: Tablets

Brand: Vorier

2. Product Description

Vorier 200mg Tablet contains Voriconazole, a broad-spectrum triazole antifungal medication. It is primarily used to treat serious, invasive fungal infections such as aspergillosis, candidiasis, and infections caused by Scedosporium or Fusarium species in immunocompromised patients.

Voriconazole works by inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, leading to cell death.

This medication is typically prescribed in hospital or clinical settings for high-risk fungal infections and should be used under medical supervision.

3. Product Highlights

Generic Name: Voriconazole

Strength: 200 mg

Dosage Form: Oral tablet

Packaging Type: Blister strip in a carton

Therapeutic Category: Antifungal / Systemic Antimicrobial

Application Area: Systemic use (oral)

Formulation: White to off-white, round, film-coated tablet

Storage Conditions:

• Store below 30C

• Keep in original packaging

• Protect from moisture and direct sunlight

Shelf Life: 24 to 36 months

Regulatory Compliance: WHO GMP / USFDA approved facility

4. Therapeutic Uses

• Treatment of invasive aspergillosis

• Treatment of candidemia in non-neutropenic patients

• Fungal infections resistant to other antifungals

• Empiric antifungal therapy in febrile neutropenic patients

Note: Use only under prescription by a specialist (infectious disease or internal medicine).

5. Safety Profile & Side Effects

Common adverse effects:

• Visual disturbances (blurry vision, photophobia)

• Fever, rash, nausea

• Liver enzyme elevation (monitor LFTs)

Serious risks:

• Hepatotoxicity

• QT prolongation (risk of arrhythmia)

• Severe allergic reactions

• Skin reactions including Stevens-Johnson syndrome (rare)

Monitoring Required:

• Liver function

• Renal function

• Electrolytes

• Drug interactions (CYP450 metabolism)

6. Precautions

• Use caution in patients with liver dysfunction

• Avoid use in pregnancy and breastfeeding

• Not recommended with certain drugs like rifampin, carbamazepine, or long-acting barbiturates

• Adjust dose in renal and hepatic impairment

• Avoid driving or operating machinery due to possible vision disturbances

• Requires regular blood monitoring in long-term use