Celginase 10000IU Injection

Product Description

1. Technical Specifications

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2. Product Description

Celginase 10,000 IU Injection contains L-Asparaginase, an enzyme-based antineoplastic drug. It works by depleting the amino acid asparagine, which is essential for the survival of certain cancer cells (particularly lymphoblasts). Since malignant lymphoid cells cannot synthesize asparagine, they undergo cell death, whereas normal cells are less affected.

It is widely used as part of multi-agent chemotherapy regimens for acute lymphoblastic leukemia (ALL) in children and adults.

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3. Product Highlights

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4. Therapeutic Uses

• Acute Lymphoblastic Leukemia (ALL) frontline and relapsed cases, in combination chemotherapy regimens (e.g., with vincristine, prednisone, daunorubicin, etc.).

• Occasionally studied in other lymphoid malignancies under specialist guidance.

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5. Side Effects

Common:

• Nausea, vomiting

• Fever, chills

• Loss of appetite, weight loss

• Fatigue, weakness

Hematologic:

• Coagulation abnormalities (bleeding/clotting issues)

• Low platelet or white cell count

Serious / Severe:

• Hypersensitivity reactions (rash, anaphylaxis)

• Pancreatitis (abdominal pain, elevated amylase/lipase)

• Hepatotoxicity (elevated liver enzymes, jaundice)

• Neurotoxicity (confusion, seizures in rare cases)

• Hyperglycemia (may lead to diabetes-like symptoms)

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6. Precautions

• Hypersensitivity: High risk of allergic reactions; test dose or close monitoring required during administration.

• Liver Function: Monitor liver enzymes and bilirubin closely.

• Pancreatitis: Discontinue immediately if pancreatitis develops.

• Blood Clotting: Monitor coagulation profile (risk of bleeding or thrombosis).

• Pregnancy & Breastfeeding: Contraindicated due to potential harm to fetus/infant.

• Drug Interactions: Can increase toxicity of vincristine and methotrexate; alters effect of anticoagulants and corticosteroids.

Effective Treatment for Adults

Celginase 10000IU Injection is tailored for adult patients requiring enzyme therapy, particularly in oncology settings. Its formulation helps inhibit the growth of certain cancer cells, making it an essential part of many chemotherapy protocols. When used as prescribed by healthcare professionals, it plays a valuable supportive role during cancer treatment. Always follow medical advice and consult your doctor for detailed usage instructions.


Proper Handling and Storage

This medication must be stored in a cool and dry environment to preserve its potency. As the solution is sensitive to temperature and humidity, proper storage ensures its effectiveness and safety for patient use. Wholesale and distribution channels throughout India are well-equipped to supply Celginase while maintaining stringent quality standards during transport and storage. For best results, keep the injection away from direct sunlight and heat.