Vincristine 1mg

Product Description

1. Technical Specifications

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2. Product Description

Vinlon 1 Injection contains Vincristine Sulphate, a vinca alkaloid derived from the periwinkle plant Catharanthus roseus.
It works by binding to tubulin and inhibiting microtubule formation, thereby arresting cells in metaphase and preventing cancer cell division.

It is widely used in combination chemotherapy protocols for leukemia, lymphoma, sarcomas, and solid tumors.

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3. Product Highlights

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4. Therapeutic Uses

• Acute Lymphoblastic Leukemia (ALL) part of induction and maintenance therapy

• Hodgkins & Non-Hodgkins Lymphoma

• Neuroblastoma

• Wilms Tumor

• Rhabdomyosarcoma

• Ewings Sarcoma

• Small Cell Lung Cancer (SCLC) (as part of combination regimens)

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5. Side Effects

Common:

• Hair loss (alopecia)

• Constipation, abdominal pain

• Nausea, vomiting, loss of appetite

• Mouth ulcers (stomatitis)

• Fatigue

Serious / Severe:

• Neurotoxicity peripheral neuropathy (tingling, numbness, foot drop, jaw pain)

• Paralytic ileus (intestinal blockage)

• Seizures, confusion (rare CNS toxicity)

• Bone marrow suppression (usually mild with vincristine compared to other chemo drugs)

• SIADH (syndrome of inappropriate ADH secretion) low sodium levels

• Extravasation severe tissue necrosis if leakage outside vein

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6. Precautions

• Route of Administration: IV only. Fatal if given intrathecally. Strict labeling and handling precautions required.

• Neuropathy Monitoring: Check for numbness, tingling, muscle weakness before each cycle.

• Bowel Function: Monitor for constipation; prophylactic laxatives may be required.

• Pregnancy & Breastfeeding: Contraindicated teratogenic.

• Drug Interactions: Avoid strong CYP3A inhibitors (e.g., itraconazole, clarithromycin) may increase neurotoxicity.

• Dose Adjustment: Required in patients with hepatic impairment.

Proper Storage Guidelines

To maintain the effectiveness of Vincristine 1mg Injection, store it in a cool and dry place, away from direct heat and light. Adhering to these guidelines helps preserve its stability, ensuring maximum therapeutic benefit and safety during distribution and use.


Usage and Administration

Vincristine 1mg should only be administered by qualified healthcare professionals, strictly following the dosage and method specified by the physician. The injectable form offers precise delivery of medication, vital for treatments involving adults with certain cancers.


Intended Users and Applications

This product is specifically recommended for doctors and is suitable for adult patients requiring chemotherapeutic interventions. Distributors, exporters, suppliers, traders, and wholesalers operating in India must ensure compliance with regulatory protocols and professional standards.