Daruvir 600 Mg Tablets

Product Description

1. Technical Specifications

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2. Product Description

Daruvir-R Tablet is a fixed-dose combination of Darunavir (600 mg) and Ritonavir (100 mg).

• Darunavir is a protease inhibitor that prevents HIV protease enzyme from cleaving viral polyproteins, leading to production of immature, non-infectious viral particles.

• Ritonavir acts as a pharmacokinetic enhancer (booster) by inhibiting CYP3A4 metabolism, thereby increasing plasma concentration and efficacy of Darunavir.

It is indicated for the treatment of HIV-1 infection in adults and adolescents, usually in combination with other antiretroviral agents.

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3. Product Highlights

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4. Therapeutic Uses

• HIV-1 Infection (in combination with other antiretrovirals):

  • First-line therapy in treatment-experienced patients.

  • Option for treatment-nave patients depending on regimen chosen.

• Helps in reducing viral load and increasing CD4 cell counts, improving immune function.

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5. Side Effects

Common:

• Nausea, vomiting, diarrhea

• Abdominal pain

• Headache, dizziness

• Rash, itching

• Fatigue

Serious / Severe:

• Severe skin reactions (Stevens-Johnson syndrome, TEN rare)

• Hepatotoxicity (jaundice, elevated liver enzymes)

• Hyperglycemia, insulin resistance

• Lipid abnormalities (high cholesterol, triglycerides)

• Pancreatitis (rare)

• Cardiac conduction abnormalities (PR interval prolongation)

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6. Precautions

• Drug Interactions: Avoid concomitant use with drugs highly dependent on CYP3A4 (e.g., simvastatin, lovastatin, rifampicin, midazolam).

• Liver Function: Monitor regularly; contraindicated in severe hepatic impairment.

• Allergy: Contraindicated in patients with known hypersensitivity to sulfonamides (Darunavir has a sulfonamide moiety).

• Pregnancy & Breastfeeding: Use with caution; breastfeeding not recommended in HIV-positive mothers.

• Metabolic Monitoring: Monitor blood glucose and lipid profile during long-term therapy.

• Adherence: Must be taken consistently with food for optimal absorption and to prevent resistance.

Versatile Supply and Distribution

Daruvir 600 Mg Tablets are available across India through various channels such as distributors, exporters, suppliers, traders, and wholesalers. This broad distribution network ensures reliable access for healthcare providers and patients alike, emphasizing quality and regulated handling throughout the supply chain.


Strict Storage and Handling

Maintaining Daruvir tablets in a cool and dry environment is essential to preserve their therapeutic properties. Proper storage reduces the risk of degradation or reduced potency, ensuring every dose administered meets clinical standards of safety and efficacy.