Ramiven 200mg Tablet

Product Description

1. Technical Specifications

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2. Product Description

Ramiven 200 mg Tablet contains Abemaciclib, a selective cyclin-dependent kinase (CDK) 4 & 6 inhibitor.
It works by blocking CDK4/6 activity, which prevents phosphorylation of the retinoblastoma protein (Rb) and stops cell cycle progression from G1 to S phase. This leads to inhibition of cancer cell proliferation.

It is primarily prescribed in hormone receptor-positive (HR+), HER2-negative advanced or metastatic breast cancer, either in combination with endocrine therapy (such as aromatase inhibitors or fulvestrant) or as monotherapy in certain cases.

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3. Product Highlights

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4. Therapeutic Uses

• HR-positive, HER2-negative advanced or metastatic breast cancer in combination with:

  • Aromatase inhibitor (first-line therapy).

  • Fulvestrant (after disease progression on prior endocrine therapy).

• May also be used as monotherapy in patients previously treated with endocrine therapy and chemotherapy.

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5. Side Effects

Common:

• Diarrhea (very frequent)

• Nausea, vomiting, abdominal pain

• Loss of appetite

• Fatigue, weakness

• Infections (due to neutropenia)

• Anemia, leukopenia, thrombocytopenia

• Headache, dizziness

Serious / Severe:

• Severe diarrhea leading to dehydration

• Neutropenia and serious infections (e.g., pneumonia, sepsis)

• Liver toxicity (elevated AST/ALT, jaundice, dark urine)

• Venous thromboembolism (DVT, pulmonary embolism)

• Rare interstitial lung disease/pneumonitis

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6. Precautions

• Blood Monitoring: Regular CBC (complete blood count) to monitor for neutropenia, anemia, and thrombocytopenia.

• Liver Function: Monitor LFTs (AST, ALT, bilirubin) periodically.

• Diarrhea Management: Start antidiarrheal treatment (loperamide) promptly at first loose stool; dose adjustments may be required.

• Thrombosis Risk: Monitor for symptoms of clotting (leg swelling, chest pain, shortness of breath).

• Pregnancy & Breastfeeding: Contraindicated; may cause fetal harm.

• Drug Interactions: Avoid strong CYP3A inhibitors (e.g., ketoconazole) and inducers (e.g., rifampicin) as they affect abemaciclib metabolism.

• Driving / Machinery: May cause dizziness or fatigue avoid hazardous activities if affected.

Trusted Indian Origin and Quality

Ramiven 200mg Tablet is manufactured in India under stringent quality standards, making it a favored choice among distributors, suppliers, and healthcare professionals. The tablet leverages 100% yeast as its primary ingredient, ensuring natural and consistent efficacy. Its Indian origin guarantees access to a reliable and affordable health solution.


Safe Storage and Long Shelf Life

Store Ramiven 200mg Tablet in a cool and dry environment to preserve its effectiveness. With a shelf life of one year, users can be confident of the products stability when stored properly. Proper storage safeguards the therapeutic properties and ensures the tablet is fit for use throughout its designated period.