Product Description

1. Technical Specifications

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2. Product Description

Cytosar-U contains Cytarabine, an antimetabolite chemotherapy drug belonging to the pyrimidine analog class.
It interferes with DNA synthesis by incorporating into DNA and inhibiting DNA polymerase, leading to impaired DNA replication and apoptosis of rapidly dividing cells.

It is a key component of induction and consolidation chemotherapy in acute leukemias and lymphomas.

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3. Product Highlights

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4. Therapeutic Uses

• Acute Myeloid Leukemia (AML): Used in induction (e.g., 7+3 regimen with daunorubicin) and consolidation therapy.

• Acute Lymphoblastic Leukemia (ALL): In certain regimens, especially in CNS prophylaxis.

• Non-Hodgkin Lymphoma (NHL): As part of salvage chemotherapy regimens.

• Chronic Myeloid Leukemia (CML): Used in blast crisis.

• Intrathecal Use: For CNS leukemia prophylaxis and treatment.

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5. Side Effects

Common:

• Nausea, vomiting, diarrhea

• Stomatitis, mouth ulcers

• Fever, malaise

• Rash, local irritation at injection site

Serious / Severe:

• Myelosuppression: severe neutropenia, anemia, thrombocytopenia

• Neurotoxicity: cerebellar toxicity (ataxia, slurred speech), especially with high doses

• Hepatotoxicity and elevated liver enzymes

• Pulmonary toxicity: pneumonitis, ARDS (high-dose regimens)

• Ocular toxicity: conjunctivitis, keratitis (prophylaxis with corticosteroid eye drops recommended in high-dose regimens)

• Tumor lysis syndrome in high-burden leukemia

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6. Precautions

• Bone marrow monitoring: CBC required frequently; dose modifications as needed.

• Neurologic monitoring: Assess coordination and mental status in high-dose regimens.

• Liver & Kidney function: Dose adjustment may be necessary in impairment.

• Pregnancy & Breastfeeding: Contraindicated; cytarabine is teratogenic.

• Eye protection: Corticosteroid eye drops recommended with high-dose therapy.

• Drug Interactions: May interact with other myelosuppressive or hepatotoxic agents.

• Intrathecal Administration: Must be preservative-free; given only in specialized centers.

Precision Medicine for Cancer Care

Cytarabine injection is pivotal in the treatment protocols for certain leukemias, offering targeted action against abnormal cells. As a trusted choice among healthcare professionals, this injectable chemotherapy agent ensures high standards of efficacy and patient safety when administered under clinical supervision.


Usage and Safety Guidelines

Cytarabine injection must only be used as per a doctors instructions. The correct dosage and administration schedule are critical for treatment effectiveness and minimizing side effects. Professionals handling this product should be well-versed in oncological protocols to ensure proper patient care.


Supply and Storage Information

Distributed and supplied across India, Cytarabine injection is available for medical institutions, clinics, and specialist wholesalers. To ensure product integrity, it must be stored in a cool, dry place according to manufacturer guidelines. Proper storage preserves its potency and extends shelf life.