Colistimethate Sodium Injection IP 1 Million IU (Xylistin)

Product Description

1. Technical Specifications

---

2. Product Description

Colistimethate Sodium Injection IP (Xylistin) is an antibiotic belonging to the polymyxin group. It is used for the treatment of severe bacterial infections caused by multidrug-resistant Gram-negative bacteria, particularly Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae. It is often reserved as a last-line therapy in critically ill patients, especially in hospital/ICU settings.

---

3. Product Highlights

---

4. Therapeutic Uses

• Hospital-acquired pneumonia (including ventilator-associated pneumonia)

• Bloodstream infections (septicemia)

• Complicated urinary tract infections

• Intra-abdominal infections

• Infections caused by multidrug-resistant Gram-negative bacteria (Pseudomonas, Acinetobacter, Klebsiella)

---

5. Side Effects

Common: Pain at injection site, numbness, dizziness, mild skin rash, itching.

Serious:

• Nephrotoxicity (kidney damage)

• Neurotoxicity (seizures, tingling, muscle weakness, confusion)

• Respiratory muscle weakness (rare but serious)

• Allergic reactions (swelling, difficulty breathing, anaphylaxis)

---

6. Precautions

• Strictly for hospital/ICU use under infectious disease specialist supervision.

• Contraindicated in patients with hypersensitivity to polymyxins.

• Dose adjustment required in patients with renal impairment.

• Caution in patients with neuromuscular disorders (e.g., myasthenia gravis).

• Avoid concurrent use with other nephrotoxic or neurotoxic drugs (e.g., aminoglycosides, vancomycin).

• Regular monitoring of kidney function and neurological status is essential.

Effective Solution for Resistant Infections

Colistimethate Sodium Injection IP 1 Million IU (Xylistin) is formulated to combat serious infections that do not respond to standard antibiotics. This injection is exclusively for adult patients and must be administered in a healthcare setting under a doctors guidance.


Strict Storage and Handling Requirements

Ensure Xylistin injections are stored in a cool, dry place to maintain their stability and effectiveness. Proper storage is crucial for safe administration and to prevent deterioration of the medication. Follow any additional handling instructions provided.


Trusted Distribution Across India

Xylistin is distributed, exported, and supplied through authorized channels throughout India. Wholesalers, traders, and suppliers ensure that this critical antibiotic is available to healthcare institutions nationwide, supporting the fight against resistant infections.