Virolfi 450mg Tablet

Product Description

1. Technical Specifications

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2. Product Description

Virolfi 450 mg Tablet is an oral antiviral medication that is converted into Ganciclovir in the body. It works by inhibiting cytomegalovirus (CMV) DNA replication, thereby preventing viral multiplication.
It is primarily prescribed for the treatment of CMV retinitis in adults with AIDS and for prevention of CMV infection in organ transplant recipients, especially when the donor is CMV-positive.

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3. Product Highlights

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4. Therapeutic Uses

• Treatment of CMV retinitis in AIDS patients

• Prophylaxis of CMV infection in solid organ transplant recipients, usually during the first 100200 days post-transplant

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5. Side Effects

Common:

• Nausea, vomiting, diarrhea

• Headache, fever

• Fatigue, insomnia, appetite loss

• Anemia, neutropenia, thrombocytopenia (low blood counts)

Serious / Severe:

• Shortness of breath, swelling of legs

• Seizures, decreased urine output

• Severe allergic reactions, itching, back pain

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6. Precautions

• Kidney Function: Dose adjustments and regular monitoring required in renal impairment

• Liver Function: Use cautiously in hepatic impairment

• Pregnancy & Breastfeeding: Contraindicated due to risk of harm to fetus or infant; reliable contraception required during treatment and for at least 30 days after therapy

• Drug Interactions:

  • Increased kidney toxicity with cidofovir and tenofovir alafenamide

  • Reduced effectiveness with maribavir

  • Increased infection risk with immunosuppressants (clozapine, infliximab, etanercept)

  • Increased blood-related toxicity with zidovudine

Key Benefits of Virolfi 450mg Tablet

Virolfi 450mg Tablet offers effective protection against cytomegalovirus (CMV) infection, specifically in adult patients who have undergone an allogeneic hematopoietic stem cell transplant (HSCT). By preventing CMV, it helps reduce the risk of serious complications, ensuring a healthier post-transplant recovery. Its antiviral action is clinically proven for prophylaxis when prescribed correctly by a physician.


How to Use Virolfi 450mg Tablet

Virolfi 450mg Tablet should be taken orally, as directed by your doctor. It is important not to exceed the prescribed dosage, and the tablets should be consumed whole without crushing or chewing. Regular adherence to the medication schedule and storing the tablets below 30C, away from moisture and light, are crucial for maintaining efficacy.


Safety and Storage Guidelines

Virolfi 450mg Tablet must not be used by individuals with known hypersensitivity to Letermovir or any tablet excipient. For safety, always consult the prescribing physician and keep these tablets out of reach of children. Proper storage conditions ensure potency throughout the shelf life; protect from direct sunlight and excessive moisture.