Vingraf 2mg Capsule

Product Description

1. Technical Specifications

2. Product Description

Vingraf 2 mg Capsule contains Tacrolimus, an immunosuppressant that works by inhibiting calcineurin, thereby suppressing T-lymphocyte activation. This reduces immune responses and prevents the body from rejecting transplanted organs. It is widely used in post-transplant care to maintain graft survival and reduce the risk of organ rejection.

3. Product Highlights

4. Therapeutic Uses

• Prevention of organ rejection in kidney, liver, and heart transplant patients

• Sometimes used in rescue therapy for patients not responding to other immunosuppressants

• May be prescribed in certain autoimmune conditions (off-label, under specialist supervision)

5. Side Effects

Common: Tremors, headache, nausea, diarrhea, high blood pressure, increased blood sugar, insomnia.

Serious:

• Nephrotoxicity (kidney damage)

• Neurotoxicity (seizures, confusion, neuropathy)

• Increased risk of infections due to immune suppression

• Diabetes mellitus post-transplant

• Increased risk of malignancies (e.g., lymphoma, skin cancer)

• Electrolyte imbalances (high potassium, low magnesium)

6. Precautions

• To be taken strictly under supervision of a transplant specialist.

• Regular monitoring of tacrolimus blood levels, kidney function, liver function, and electrolytes is required.

• Dose adjustments may be needed depending on drug levels and patient condition.

• Avoid grapefruit and grapefruit juice (alters tacrolimus metabolism).

• Contraindicated in patients with hypersensitivity to Tacrolimus.

• Increased risk of drug interactions (CYP3A4 inhibitors/inducers).

• Patients should avoid excessive sunlight exposure (risk of skin cancer).