Tigez 50 Mg Injection

Product Description

1. Technical Specifications

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2. Product Description

Tigez 50 mg Injection contains Tigecycline, a broad-spectrum glycylcycline antibiotic structurally related to tetracyclines. It acts by binding to the 30S ribosomal subunit, thereby inhibiting bacterial protein synthesis and preventing bacterial growth.

It is given intravenously after reconstitution and is reserved for complicated infections due to its broad activity against multi-drug resistant organisms.

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3. Product Highlights

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4. Therapeutic Uses

• Complicated intra-abdominal infections

• Complicated skin and soft tissue infections

• Community-acquired pneumonia (when alternatives are unsuitable)

• Active against many resistant pathogens: MRSA, VRE, ESBL-producing organisms

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5. Side Effects

Common:

• Nausea, vomiting, diarrhea

• Headache, dizziness

• Injection site reactions

• Increased liver enzymes

Serious / Severe:

• Pancreatitis

• Severe hepatic impairment

• Increased risk of mortality in some severe infections (black box warning)

• Superinfections including Clostridioides difficile-associated diarrhea

• Hypersensitivity or anaphylaxis (rare)

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6. Precautions

• Liver Function: Dose adjustment required in severe hepatic impairment. Monitor liver enzymes regularly.

• Pregnancy & Breastfeeding: Contraindicated; potential teratogenic effects and excretion in breast milk.

• Children: Not recommended in patients <8 years due to tooth discoloration and bone growth issues.

• Drug Interactions: Use with caution alongside anticoagulants (may increase INR). Avoid with other hepatotoxic agents.

• Resistance: Not for routine use in mild infections; reserve for resistant cases.

• Mortality Risk: Studies show higher mortality in serious infectionsshould be used when no alternatives are available.

Therapeutic Application of Tigez 50 Mg Injection

Tigez 50 Mg Injection is utilized in clinical settings to manage severe bacterial infections, particularly those affecting the skin, soft tissue, and abdominal area. Its broad-spectrum antibacterial properties make it effective against various resistant pathogens, underscoring its significance for patients with complicated health conditions seeking targeted therapy.


Proper Use and Preparation

Before administration, Tigez 50 Mg Injection must be reconstituted with sterile water for injection as per the guidelines. This process ensures the correct concentration for intravenous delivery. Only trained healthcare professionals should handle preparation and administration to optimize efficacy and minimize risks associated with improper use.


Safe Storage and Shelf Life

Maintaining the stability of Tigez 50 Mg Injection requires strict storage below 25C and protection from light. Each glass vial is engineered to preserve the medicines integrity for up to 24 months. Following these instructions reduces the risk of degradation, ensuring the medications optimal performance when needed.