Alkeran 2mg Tablet

About Alkeran 2mg Tablet

1. Technical Specifications

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2. Product Description

Alkeran (Melphalan) is an alkylating agent from the nitrogen mustard derivative class.
It works by cross-linking DNA strands, thereby inhibiting DNA replication and RNA transcription, which leads to impaired protein synthesis and cell death.

It is primarily used in the treatment of multiple myeloma, ovarian cancer, and as part of conditioning regimens for bone marrow transplantation.

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3. Product Highlights

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4. Therapeutic Uses

• Multiple Myeloma standard therapy, often in combination with prednisone or other agents.

• Ovarian Cancer in advanced or relapsed cases.

• Breast Cancer palliative use in selected patients.

• Polycythemia Vera used in certain resistant cases.

• Conditioning for Hematopoietic Stem Cell Transplantation in high-dose regimens (usually IV melphalan form).

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5. Side Effects

Common:

• Nausea, vomiting, diarrhea

• Loss of appetite

• Mouth ulcers, stomatitis

• Hair loss (alopecia)

• Skin rash, pigmentation changes

• Fatigue, weakness

Serious / Severe:

• Bone marrow suppression leukopenia, neutropenia, thrombocytopenia, anemia

• Severe infections due to low immunity

• Pulmonary fibrosis (rare but serious)

• Secondary malignancies (long-term use risk: leukemia)

• Hypersensitivity reactions (rare, but may occur with oral or IV formulations)

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6. Precautions

• Monitoring: CBC (complete blood count) before and during treatment; dose modifications needed for cytopenias.

• Renal Impairment: Dose adjustment required.

• Hepatic Impairment: Caution advised.

• Pregnancy & Breastfeeding: Contraindicated (teratogenic, mutagenic, carcinogenic). Effective contraception required.

• Handling: Cytotoxicspecial care required in handling and disposal.

• Drug Interactions: Avoid live vaccines; caution with other bone marrow-suppressive agents.

High-Quality Indian Origin

Sourced and manufactured in India, Alkeran 2mg Tablet meets strict quality controls, ensuring a reliable supply for healthcare providers and distributors. Exported worldwide by trusted partners, it remains a popular choice among medical suppliers.


Optimal Storage & Shelf Life

To preserve the efficacy and integrity of Alkeran 2mg Tablet, always store it in a cool and dry place. When stored properly, the tablet remains potent and safe for up to one year from the manufacturing date, as recommended by the supplier.


Distinctive Ingredient & Smell

Each Alkeran 2mg Tablet contains 100% yeast, resulting in a characteristic, yet normal, fermentation aroma. This natural ingredient underscores the tablets purity and adherence to recommended formulation standards.