Rhoclone 300 Mcg Injection

Product Description

1. Technical Specifications

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2. Product Description

Rhoclone 300 mcg Injection contains Anti-D Immunoglobulin (Human), a blood product prepared from human plasma. It is given to Rh-negative mothers to prevent Rh isoimmunization that may occur during pregnancy or delivery if the baby is Rh-positive. This prevents the formation of antibodies that could harm current or future pregnancies.

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3. Product Highlights

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4. Therapeutic Uses

• Prevention of Rh isoimmunization in Rh-negative mothers after:

  • Delivery of an Rh-positive baby

  • Miscarriage, abortion, or ectopic pregnancy

  • Amniocentesis, chorionic villus sampling, or intrauterine procedures

• Hemolytic Disease of the Newborn (HDN) prevention in future pregnancies

• Used in transfusion medicine when Rh-negative patients are accidentally given Rh-positive blood

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5. Side Effects

Common:

• Mild pain, redness, or swelling at injection site

• Low-grade fever, headache

• Malaise, tiredness

Serious (rare):

• Allergic reactions (rash, itching, hives)

• Anaphylaxis (very rare, requires emergency treatment)

• Hemolysis in Rh-positive patients if injected mistakenly

• Transmission risk of infections (extremely rare, as plasma is screened and processed)

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6. Precautions

• Use only under medical supervision

• Contraindicated in Rh-positive individuals and patients with IgA deficiency with antibodies against IgA

• Must be administered within 72 hours of delivery/exposure for maximum effectiveness

• Monitor for allergic reactions post-injection

• Use with caution in patients with bleeding disorders or thrombocytopenia

• Vaccine interactions: Live vaccines (e.g., measles, mumps, rubella) should be delayed for at least 3 months after Anti-D administration

Purpose and Indication

Rhoclone 300 Mcg Injection is specifically designed for the prevention of Rh (D) alloimmunization in Rh-negative pregnant women or those undergoing delivery, abortion, or any obstetric procedures where exposure to Rh-positive blood may occur. This immunoprophylaxis helps protect future pregnancies from complications related to Rh incompatibility.


Administration Guidelines

The injection must be administered intramuscularly by a qualified healthcare professional, typically in a medical setting. Each pre-filled syringe provides a single dose of 300 mcg (1500 IU). Accurate timing as recommended by clinical guidelines is essential for optimal protection. The product is supplied in a colorless to pale yellow, odorless solution.


Storage and Safety

Store Rhoclone Injection at 2C to 8C and avoid freezing. Use is restricted to Rh-negative women and should not be given to Rh-positive individuals. Caution is necessary for patients with known allergies to immunoglobulin products. Always follow prescription requirements and handle under professional supervision.