Tafnat 25 Mg Tablet

उत्पाद विवरण

1. Technical Specifications

2. Product Description

Tafnat 25 mg Tablet contains Tenofovir Alafenamide (TAF), a nucleotide reverse transcriptase inhibitor (NRTI).
It is primarily used in the treatment of chronic Hepatitis B virus (HBV) infection and in combination with other antiretroviral medicines for HIV-1 infection.

Compared to Tenofovir Disoproxil Fumarate (TDF), TAF is a newer prodrug with higher efficacy at lower doses and reduced risk of kidney and bone side effects.

3. Product Highlights

4. Therapeutic Uses

• HIV-1 Infection: Used in combination with other ARVs as part of HAART regimen

• Chronic Hepatitis B Infection: Reduces viral load, prevents liver damage and cirrhosis

• Prevention of HIV Transmission (PrEP): Sometimes used in combination regimens

5. Side Effects

Common:

• Headache, nausea, abdominal pain

• Fatigue

• Diarrhea

Serious (rare):

• Lactic acidosis (very rare)

• Severe liver problems (hepatomegaly, steatosis)

• Kidney dysfunction (less frequent than TDF)

• Bone mineral density loss (less compared to TDF)

6. Precautions

• Use under specialist supervision for HIV/HBV treatment

• Monitor liver function and kidney function regularly

• Caution in patients with pre-existing liver or kidney disease

• Avoid sudden discontinuation in HBV patients (can cause severe flare-up of hepatitis)

• Not recommended in pregnancy unless prescribed by physician

• Avoid concomitant use with strong P-gp inducers (e.g., rifampin, carbamazepine, phenytoin) as they reduce drug levels