उत्पाद विवरण
1. Technical Specifications
| Attribute |
Details |
| Brand Name |
Akynzeo 300mg/0.5mg Capsule |
| Generic Name |
Netupitant 300 mg + Palonosetron 0.5 mg |
| Strength |
Netupitant 300 mg + Palonosetron 0.5 mg (fixed-dose combination) |
| Dosage Form |
Oral Capsule |
| Packaging Size |
1 capsule per blister / pack |
| Packaging Type |
Blister pack in carton box |
| Medicine Type |
Antiemetic (NK1 receptor antagonist + 5-HT3 receptor antagonist) |
| Manufacturer |
Helsinn Healthcare SA (Switzerland) / Marketed globally by Novartis & partners |
| Distributed By |
Authorized oncology distributors & specialty hospital pharmacies |
2. Product Description
Akynzeo Capsule is a fixed-dose oral antiemetic combining Netupitant (NK1 receptor antagonist) and Palonosetron (5-HT3 receptor antagonist).
It works by blocking substance P at NK1 receptors and serotonin at 5-HT3 receptors, offering broad protection against both acute and delayed chemotherapy-induced nausea and vomiting (CINV).
3. Product Highlights
| Attribute |
Details |
| Therapeutic Category |
Antiemetic (CINV prevention) |
| Application Area |
Prevention of acute and delayed nausea & vomiting with highly and moderately emetogenic chemotherapy |
| Mechanism of Action |
- Netupitant: Inhibits NK1 receptors in CNS prevents binding of substance P reduces delayed nausea/vomiting |
-
Palonosetron: High-affinity, long half-life 5-HT3 antagonist blocks serotonin signaling in GI tract & CNS prevents acute nausea/vomiting
Administration | 1 capsule orally about 1 hour before chemotherapy, with or without food (usually combined with dexamethasone)
Storage Conditions | Store below 30 C, protect from moisture, keep in original packaging
4. Therapeutic Uses
-
Acute CINV prevention: within 24 hrs of chemotherapy
-
Delayed CINV prevention: up to 5 days post-chemotherapy
-
Recommended for highly emetogenic regimens (e.g., cisplatin-based) and moderately emetogenic regimens
5. Side Effects
Common:
-
Headache
-
Constipation
-
Fatigue
-
Dyspepsia (indigestion)
-
Hiccups
Serious / Severe:
-
Hypersensitivity or allergic reactions (rare, but possible)
-
Hepatic enzyme elevation (AST/ALT increase)
-
Rare QT prolongation / cardiac rhythm disturbances
-
Severe constipation or bowel obstruction (rare)
6. Precautions
-
Hepatic Monitoring: Use cautiously in patients with liver impairment.
-
Drug Interactions:
-
Netupitant is a CYP3A4 inhibitor increases plasma levels of dexamethasone, docetaxel, etoposide, vincristine, etc. (dose adjustments required).
-
Avoid strong CYP3A4 inducers (rifampicin, phenytoin, carbamazepine) and inhibitors (ketoconazole, clarithromycin).
-
Cardiac Caution: Monitor ECG in patients with risk factors or on QT-prolonging drugs.
-
Pregnancy & Breastfeeding: Contraindicated; safety not established.
-
Repeat Dosing: Should not be repeated within 2 weeks; used once per chemotherapy cycle.
Dual Action for Powerful Nausea ControlCombining Netupitant and Palonosetron Hydrochloride, these capsules provide a dual mechanism that targets both acute and delayed phases of chemotherapy-induced nausea and vomiting. This synergy results in improved patient comfort and minimizes interruptions during chemotherapy cycles.
Simple and Effective DosingA single oral dose of the capsule is taken approximately one hour prior to starting your chemotherapy session, as prescribed by your doctor. This straightforward dosing regimen helps eliminate the complexity of repeated antiemetic administrations throughout the cycle.
Safety and Regulatory ApprovalThis medicine meets stringent standards and is approved by relevant regulatory authorities, ensuring its quality and safety for adults. It is distributed and supplied under strict guidelines across India by trusted wholesalers and exporters, offering both reliability and peace of mind.
FAQs of Netupitant and Palonosetron Hydrochloride capsule:
Q: How should Netupitant and Palonosetron Hydrochloride capsules be taken for best results?
A: For optimal effectiveness, take one capsule orally about one hour before your scheduled chemotherapy session, following your physicians instructions. Do not exceed the prescribed dosage.
Q: What is the primary benefit of using these capsules during chemotherapy?
A: These capsules are specifically designed to prevent both immediate (acute) and delayed nausea and vomiting, helping patients maintain quality of life and adhere to their chemotherapy treatment plans.
Q: When is the right time to start taking this medication?
A: The capsule should be taken as a single dose, about one hour before starting your chemotherapy, in accordance with your healthcare providers guidance.
Q: Where should these capsules be stored to maintain their effectiveness?
A: Store the capsules in a cool, dry place, protected from direct light and moisture, to ensure they remain potent until their expiry date.
Q: What cautions should be observed while using this medicine?
A: This product is only for adult use and should not be taken by children or pregnant women unless prescribed by a healthcare professional. Always follow your doctors advice and keep it out of reach of children.
Q: Who can prescribe or supply Netupitant and Palonosetron Hydrochloride capsules?
A: This medication is a prescription-only drug and should be prescribed by a certified healthcare provider. It is distributed and supplied by licensed distributors, exporters, and wholesalers across India.
Q: What is the process if a dose is missed before chemotherapy?
A: If you miss your scheduled dose, consult your healthcare provider immediately for guidance. Do not double up on the medication or take it outside of the recommended timeframe without medical supervision.
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