Entehep 0.5mg Tablets

उत्पाद विवरण

1. Technical Specifications

2. Product Description

Entehep 0.5mg Tablet contains Entecavir, a potent oral antiviral medication belonging to the nucleoside analogue class. It works by inhibiting HBV DNA polymerase enzyme, thereby blocking viral replication in hepatitis B virus (HBV).

It is mainly prescribed for the treatment of chronic hepatitis B infection in adults and children above 2 years, especially in those with active viral replication and liver damage.

3. Product Highlights

4. Therapeutic Uses

• Chronic Hepatitis B (CHB):

  • In adults with evidence of active viral replication and liver inflammation or fibrosis.

  • In patients resistant or intolerant to other antivirals (e.g., lamivudine).

• Helps in reducing liver damage, progression to cirrhosis, and risk of liver cancer.

5. Side Effects

Common:

• Headache

• Fatigue, dizziness

• Nausea, indigestion

• Sleep problems

• Elevated liver enzymes (transient)

Serious / Severe:

• Lactic acidosis (rare, potentially life-threatening)

• Severe liver enlargement (hepatomegaly with steatosis)

• Exacerbation of hepatitis upon stopping therapy

• Kidney function impairment (long-term use risk)

6. Precautions

• Renal Function: Dose adjustment required in kidney impairment.

• Liver Monitoring: Regular liver function tests are necessary.

• Treatment Discontinuation: May cause HBV flare-up must be tapered/stopped only under medical supervision.

• Pregnancy & Breastfeeding: Use with caution; safety data limited.

• Drug Interactions: Avoid with other nephrotoxic drugs (e.g., aminoglycosides, NSAIDs in high doses).

• Long-Term Use: Resistance is rare but possible; adherence is crucial.