Avastin 100mg Injection

उत्पाद विवरण

1. Technical Specifications

2. Product Description

Avastin 100mg Injection contains Bevacizumab, a recombinant humanized monoclonal antibody that specifically binds to vascular endothelial growth factor (VEGF-A).
By inhibiting VEGF-A, Avastin prevents the growth of new blood vessels (angiogenesis) that tumors need for oxygen and nutrients, thereby suppressing tumor growth and metastasis.

It is used in multiple advanced cancers, often in combination with chemotherapy.

3. Product Highlights

4. Therapeutic Uses

• Metastatic Colorectal Cancer (with fluoropyrimidine-based chemo)

• Non-Small Cell Lung Cancer (NSCLC) (non-squamous, advanced/metastatic) with platinum-based chemo

• Glioblastoma (as single agent in recurrent disease)

• Metastatic Renal Cell Carcinoma (with interferon alfa)

• Persistent, Recurrent, or Metastatic Cervical Cancer (with chemo)

• Ovarian, Fallopian Tube, or Peritoneal Cancer (first-line, relapsed, platinum-sensitive/resistant cases with chemo)

5. Side Effects

Common:

• Hypertension

• Fatigue, headache

• Proteinuria (protein in urine)

• Nosebleeds, minor bleeding

• Delayed wound healing

• Diarrhea, abdominal pain

Serious / Severe:

• Gastrointestinal perforation (rare but life-threatening)

• Hemorrhage (serious bleeding)

• Thromboembolic events (stroke, heart attack)

• Severe hypertension & hypertensive crisis

• Nephrotic syndrome due to proteinuria

• Reversible posterior leukoencephalopathy syndrome (RPLS rare brain condition)

6. Precautions

• Wound Healing: Do not initiate within 28 days of major surgery; discontinue in case of wound healing complications.

• Hypertension: Monitor blood pressure regularly; treat as required.

• Proteinuria: Regular urine protein monitoring advised.

• Bleeding Risk: Use with caution in patients with recent hemoptysis, bleeding disorders, or anticoagulant therapy.

• Pregnancy & Breastfeeding: Contraindicated; may harm fetus (VEGF inhibition can impair fetal development).

• Drug Interactions: Generally low, since it is a monoclonal antibody, but caution with other myelosuppressive/anti-angiogenic drugs.