Avapritinib Tablet 200 Mg

Product Description

1. Technical Specifications

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2. Product Description

Avapritinib is a selective tyrosine kinase inhibitor (TKI) that specifically targets PDGFRA exon 18 mutations (including D842V) and KIT mutations. It is an oral precision therapy used for the treatment of gastrointestinal stromal tumors (GIST) with certain genetic alterations and systemic mastocytosis (SM) in selected cases.

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3. Product Highlights

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4. Therapeutic Uses

• Gastrointestinal Stromal Tumors (GIST): Specifically indicated for unresectable or metastatic GIST harboring a PDGFRA exon 18 mutation (including the D842V mutation).

• Systemic Mastocytosis (SM): Treatment of advanced systemic mastocytosis, aggressive SM, SM with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL).

• Investigational/expanded use in other rare KIT/PDGFRA-driven malignancies.

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5. Side Effects

Common:

• Nausea, vomiting

• Diarrhea or constipation

• Fatigue

• Periorbital or peripheral edema

• Decreased appetite

• Hair color changes

Serious / Important:

• Cognitive effects: memory impairment, confusion, altered mental status (requires close monitoring).

• Intracranial bleeding (rare but serious).

• Anemia, thrombocytopenia.

• Fluid retention (ascites, pleural effusion).

• Gastrointestinal bleeding.

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6. Precautions & Monitoring

• Cognitive side effects: Monitor for confusion, memory loss, or speech difficulties. Dose interruption or reduction may be necessary.

• Bleeding risk: Use cautiously in patients with history of intracranial or GI bleeding; monitor platelets.

• Liver function: Check baseline and periodic liver function tests (ALT, AST, bilirubin).

• Pregnancy & Lactation: Can cause fetal harm; avoid use in pregnancy. Effective contraception required during and after therapy. Avoid breastfeeding.

• Drug interactions: Metabolized by CYP3A4 avoid strong inhibitors/inducers (e.g., ketoconazole, rifampin).

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7. Administration & Practical Points

• Take orally once daily on an empty stomach (at least 1 hour before or 2 hours after a meal).

• Swallow tablet whole; do not crush or split.

• If a dose is missed by more than 8 hours, skip it and resume next dose.

• Adjust dose or interrupt therapy in case of serious adverse events.

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8. Handling & Storage

• Store at room temperature (<25C), in a dry place, tightly closed.

• Keep in original container; protect from moisture.

• Handle with care; wash hands after handling.

• Unused tablets should be disposed of according to oncology medication disposal protocols.

A Trusted Treatment Option

Avapritinib Tablet 200 Mg is produced in India by skilled manufacturers who adhere to stringent quality protocols. This tablet serves a specialized role in targeted therapies, making it a preferred choice for medical professionals seeking reliable and effective pharmaceutical solutions. As a distributor, exporter, and supplier, the product is made available across a vast network within India.


Proper Storage and Lasting Quality

To guarantee maximum efficacy, Avapritinib Tablet 200 Mg should be stored in a cool and dry place. This ensures that the medication retains its effectiveness throughout its stated shelf life of one year. Following recommended storage guidelines is vital for patient safety and optimal results during treatment.