Afatinib Dimaleate 40mg tablet

Product Description

1. Technical Specifications

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2. Product Description

Xovoltib 40mg Tablet contains Afatinib, an irreversible ErbB family blocker. It selectively inhibits EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4), thereby blocking abnormal signaling pathways that drive cancer cell growth and survival.

It is prescribed for patients with EGFR mutationpositive non-small cell lung cancer (NSCLC) and is part of targeted therapy protocols.

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3. Product Highlights

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4. Therapeutic Uses

• Non-Small Cell Lung Cancer (NSCLC):

  • First-line treatment of patients with EGFR mutation-positive advanced or metastatic NSCLC.

  • May be continued until disease progression or unacceptable toxicity.

(Use strictly under oncologists supervision after confirming EGFR mutation status.)

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5. Side Effects

Common:

• Diarrhea (most frequent)

• Rash, acneiform eruption, dry skin

• Stomatitis (mouth ulcers), mucositis

• Decreased appetite, weight loss

• Paronychia (nail inflammation)

Serious / Severe:

• Severe diarrhea dehydration & electrolyte imbalance

• Interstitial Lung Disease (rare but potentially fatal)

• Liver toxicity (elevated ALT/AST)

• Severe cutaneous reactions (StevensJohnson Syndrome, rare)

• Cardiac dysfunction in predisposed patients

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6. Precautions

• EGFR Testing: Confirm EGFR mutation before starting therapy.

• Diarrhea Management: Early intervention with antidiarrheals; dose adjustments may be required.

• Liver Monitoring: Regular LFTs recommended.

• Pulmonary Monitoring: Discontinue if interstitial lung disease develops.

• Pregnancy & Lactation: Contraindicated; afatinib is teratogenic.

• Drug Interactions:

  • Avoid strong P-glycoprotein inhibitors/inducers (e.g., ritonavir, carbamazepine).

  • Use caution with other hepatotoxic drugs.

Reliable Supply Chain Across India

As a trusted distributor, exporter, supplier, trader, and wholesaler, we ensure Afatinib Dimaleate 40mg tablets are widely available for healthcare providers and pharmacies across India. We handle all logistics, maintaining quality and compliance at each stage.


Best Handling and Storage Practices

To preserve the potency and safety of Afatinib Dimaleate 40mg tablets, always store them in a cool and dry location. Keep the medication in its original packaging until use, and ensure it is out of reach from children and unauthorized individuals.


Guided Patient Usage

Usage of Afatinib Dimaleate 40mg tablets must follow explicit doctor instructions. Adult patients should only take this medicine as prescribed. Regular consultations with healthcare professionals are important for monitoring dosage and managing possible side effects.