Acalabrutinib 100 mg tablet

Product Description

1. Technical Specifications

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2. Product Description

Calquence 100mg Capsule contains Acalabrutinib, a selective Bruton Tyrosine Kinase (BTK) inhibitor.
It blocks BTK, an enzyme that plays a critical role in B-cell receptor signaling, essential for the survival and proliferation of malignant B-cells.

By inhibiting BTK, it helps control abnormal B-cell growth, making it effective in certain blood cancers such as chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL).

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3. Product Highlights

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4. Therapeutic Uses

• Mantle Cell Lymphoma (MCL): In adults who have received at least one prior therapy.

• Chronic Lymphocytic Leukemia (CLL): First-line and relapsed/refractory cases.

• Small Lymphocytic Lymphoma (SLL): Indicated for treatment.

• Under evaluation for other B-cell malignancies (clinical trials).

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5. Side Effects

Common:

• Headache

• Diarrhea, constipation

• Fatigue

• Muscle/joint pain

• Easy bruising

Serious / Severe:

• Cytopenias (low WBC, RBC, platelets risk of infections, bleeding, anemia)

• Atrial fibrillation / flutter (irregular heartbeat)

• Severe infections (bacterial, viral, fungal)

• Secondary cancers (including skin cancers)

• Intracranial hemorrhage (rare but life-threatening)

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6. Precautions

• Bleeding Risk: Increased bleeding tendency; avoid concomitant use with anticoagulants/antiplatelets unless essential.

• Infections: Monitor for fever, cough, or other infection signs; prophylaxis may be required in some patients.

• Cardiac Monitoring: Patients with history of arrhythmias should be monitored closely.

• Pregnancy & Breastfeeding: Contraindicated; may cause fetal harm.

• Drug Interactions:

  • Avoid strong CYP3A inhibitors (ketoconazole, clarithromycin) increase drug levels.

  • Avoid strong CYP3A inducers (rifampicin, phenytoin) decrease effectiveness.

  • PPIs (omeprazole, pantoprazole) reduce absorption avoid use.

• Vaccinations: Live vaccines should not be administered during treatment.

Distinctive Composition for Well-being

Acalabrutinib 100 mg tablet stands out with its pure 100% yeast ingredient, resulting in a natural fermentation smell. This composition appeals to users looking for alternative, naturally sourced formulations that maintain consistent potency and purity. The unique ingredient profile sets it apart in the pharmaceutical market.


Best Practices for Storage and Longevity

To ensure the maximum shelf life and potency of Acalabrutinib 100 mg tablets, they should be stored in a cool, dry place away from sunlight and moisture. Adhering to these storage guidelines safeguards the products effectiveness throughout its one-year shelf life, making it reliable for distributors and end users alike.